Efficacy of afoxolaner against Dermacentor variabilis ticks in dogs
نویسندگان
چکیده
منابع مشابه
Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs.
Afoxolaner is an isoxazoline compound characterized by a good safety profile and extended effectiveness against fleas and ticks on dogs following a single oral administration. In vitro membrane feeding assay data and in vivo pharmacokinetic studies in dogs established an afoxolaner blood concentration of 0.1-0.2 μg/ml to be effective against both fleas (Ctenocephalides felis) and ticks (Dermace...
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Ticks carry a wide range of known human and animal pathogens and are postulated to carry others with the potential to cause disease. Here we report a discovery effort wherein unbiased high-throughput sequencing was used to characterize the virome of 2,021 ticks, including Ixodes scapularis (n = 1,138), Amblyomma americanum (n = 720), and Dermacentor variabilis (n = 163), collected in New York, ...
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In this study we examined the efficiency of an in vitro feeding technique using glass microcapillaries as a method of establishing rickettsiae-infected lines of ticks. To quantify the volume ingested by ticks during microcapillary feeding, the incorporation of radiolabeled amino acids in tick gut and hemolymph was calculated. Fifteen of 18 ticks consumed between 0.06 and 6.77 microl. However, i...
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Exotic plants often invade areas of high human activity, such as along trails, roads, and forest edges, and in disturbed riparian areas. These same habitat types are also favored by ticks. This convergence suggests that habitat modifications caused by exotic plant invasions may mediate disease vector habitat quality, indirectly affecting human disease risk at the local spatial scale. We tested ...
متن کاملNonrandom Distribution of Vector Ticks (Dermacentor variabilis) Infected by Francisella tularensis
The island of Martha's Vineyard, Massachusetts, is the site of a sustained outbreak of tularemia due to Francisella tularensis tularensis. Dog ticks, Dermacentor variabilis, appear to be critical in the perpetuation of the agent there. Tularemia has long been characterized as an agent of natural focality, stably persisting in characteristic sites of transmission, but this suggestion has never b...
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ژورنال
عنوان ژورنال: Veterinary Parasitology
سال: 2014
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2014.02.016